Author: Giulia Nicotra

After years of research, development, and real-world applications, we have released the first official video offering a clear and accessible introduction to what UISS is, how it works, and why it matters 🧬 UISS is a mechanistic, agent-based immunological simulation platform, designed to model the human immune system in a predictive, explainable, and trustworthy way — from…
Read more

We are excited to share that our Group Leader Prof. Francesco Pappalardo serve as Chair of the Track “𝘊𝘰𝘮𝘱𝘶𝘵𝘢𝘵𝘪𝘰𝘯𝘢𝘭 𝘢𝘯𝘥 𝘈𝘐-𝘥𝘳𝘪𝘷𝘦𝘯 𝘋𝘳𝘶𝘨 𝘋𝘦𝘭𝘪𝘷𝘦𝘳𝘺 𝘢𝘯𝘥 𝘋𝘦𝘴𝘪𝘨𝘯” at the 𝟗𝐭𝐡 𝐈𝐧𝐭𝐞𝐫𝐧𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐂𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞 𝐨𝐧 𝐭𝐡𝐞 𝐕𝐢𝐫𝐭𝐮𝐚𝐥 𝐏𝐡𝐲𝐬𝐢𝐨𝐥𝐨𝐠𝐢𝐜𝐚𝐥 𝐇𝐮𝐦𝐚𝐧 (𝐕𝐏𝐇 𝟐𝟎𝟐𝟔) This is a fantastic opportunity to contribute and engage in discussions on computational and AI-driven approaches in drug delivery and drug design, within…
Read more

We are pleased to announce that Prof. Francesco Pappalardo, Leader of the Combine Group, was officially invited to speak at the Union World Conference on Lung Health 2025, one of the most influential global events dedicated to tuberculosis and respiratory health. During the conference, Prof. Pappalardo delivered a presentation titled:“In Silico Trials to Identify and…
Read more

On November 10th, 2025, our Group Leader Prof. Francesco Pappalardo delivered a keynote lecture at the 2nd International Annual Conference on Artificial Intelligence in Health (AI Health 2025). In his talk, titled “The evolving landscape of in silico medicine and its growing recognition by regulatory bodies”, Prof. Pappalardo explored how in silico medicine is gaining increasing acknowledgment from international regulatory authorities, with a…
Read more

In recent years, biomedical research has been undergoing a silent but powerful transformation.A recent Nature article “Alternatives to animal testing are the future” sends a clear message: it’s time to move beyond animal testing and embrace approaches that are more ethical, predictive, and human-centered. At the forefront of this shift stands in silico medicine the use of computational models and digital simulations to…
Read more

We are excited to share that on 5–6 November 2025, Brussels will host the 20th Anniversary Conference of the European Partnership for Alternative Approaches to Animal Testing (EPAA).For two decades, the EPAA has united the European Commission, industry, academia, and NGOs around one shared goal: promoting the “3Rs” — Replacement, Reduction and Refinement — in…
Read more

Il progetto UISS – Universal Immune System Simulator, sviluppato dal Prof. Francesco Pappalardo con il supporto del Gruppo COMBINE del Dipartimento di Scienze del Farmaco e della Salute dell’Università di Catania, è stato recentemente presentato al Parlamento Europeo durante “Excellence in Health Science”, evento promosso dal Committee on Public Health (SANT). A rappresentarlo, la prof.ssa Liesbet Geris (KU Leuven, Université de Liège), direttrice esecutiva della Virtual Physiological…
Read more