• Vaccines and Immunotherapies


    Speed-up the R&D pipeline in the development of new vaccines and immunotherapies: make predictions – optimize dosage – boosting formulation discovery.

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  • In silico clinical trials


    Development of patient-specific models to form virtual cohorts to test the safety and/or efficacy of new drugs and of new medical devices: “In silico clinical trials”, the manifesto of a revolutionary approach.

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  • Precision Medicine


    Smart identification of new molecular targets:
    novel therapies -
    overcome resistance to anticancer drugs.

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The Research Group "COmputational Modeling in systems BIomediciNE" (COMBINE for short) of the University of Catania, Department of Drug and Health Sciences, deals with computational biomedicine.

COMBINE group has developed the Universal Immune System Simulator (UISS) that is a computational framework that makes use of a multi-scale, multi-organ, three-dimensional agent based simulator of the immune system, with an attached module able to simulate the dynamics of a biological pathway at the molecular level, named COmputational StrategieS for the analysis of Biological pAthways and moleculaR surface/binding (CrOSSBAR).

UISS was applied to:

make predictions about the outcome of specific vaccination strategies;
optimize vaccine dosage for the best result in terms of efficacy and minimization of adverse effects, in a personalized fashion;
vaccine formulation discovery (both at cellular and molecular level);
optimize drug combinations to obtain maximum efficacy;
discover molecular and/or cellular targets to overcome drug resistance;

Computational Biomedicine


Department of Drug and Health Sciences, V.le A. Doria, 6, 95125 Catania, Italy

Phone Number

Office: +39 095/7384223
Lab: +39 095/7384254
Fax: +39 095/9895233

keep in touch

We are happy to answer your questions at combine@combine-group.org