COMBINE Group

COMBINE group has developed the Universal Immune System Simulator (UISS) that is a computational framework that makes use of a multi-scale, multi-organ, three-dimensional agent based simulator of the immune system, with an attached module able to simulate the dynamics of a biological pathway at the molecular level, named COmputational StrategieS for the analysis of Biological pAthways and moleculaR surface/binding (CrOSSBAR).

UISS was applied to:

• make predictions about the outcome of specific vaccination strategies;
• optimize vaccine dosage for the best result in terms of efficacy and minimization of adverse effects, in a personalized fashion;
• vaccine formulation discovery (both at cellular and molecular level);
• optimize drug combinations to obtain maximum efficacy;
• discover molecular and/or cellular targets to overcome drug resistance;