
๐ขย ๐๐๐ฅ๐ฅ ๐๐จ๐ซ ๐๐๐ฌ๐ญ๐ซ๐๐๐ญ๐ฌ โ ๐๐๐ ๐๐๐๐ | ๐๐๐ ๐๐๐๐!
We are excited to share that ourย Group Leaderย Prof. Francesco Pappalardo serve asย Chair of the Track โ๐๐ฐ๐ฎ๐ฑ๐ถ๐ต๐ข๐ต๐ช๐ฐ๐ฏ๐ข๐ญ ๐ข๐ฏ๐ฅ ๐๐-๐ฅ๐ณ๐ช๐ท๐ฆ๐ฏ ๐๐ณ๐ถ๐จ ๐๐ฆ๐ญ๐ช๐ท๐ฆ๐ณ๐บ ๐ข๐ฏ๐ฅ ๐๐ฆ๐ด๐ช๐จ๐ฏโย at theย ๐๐ญ๐ก ๐๐ง๐ญ๐๐ซ๐ง๐๐ญ๐ข๐จ๐ง๐๐ฅ ๐๐จ๐ง๐๐๐ซ๐๐ง๐๐ ๐จ๐ง ๐ญ๐ก๐ ๐๐ข๐ซ๐ญ๐ฎ๐๐ฅ ๐๐ก๐ฒ๐ฌ๐ข๐จ๐ฅ๐จ๐ ๐ข๐๐๐ฅ ๐๐ฎ๐ฆ๐๐ง (๐๐๐ ๐๐๐๐)
This is a fantastic opportunity to contribute and engage in discussions on computational and AI-driven approaches in drug delivery and drug design, within one of the leading conferences in the field
๐ย ๐๐๐ฌ๐ญ๐ซ๐๐๐ญ ๐ฌ๐ฎ๐๐ฆ๐ข๐ฌ๐ฌ๐ข๐จ๐ง๐ฌ ๐๐ซ๐ ๐ง๐จ๐ฐ ๐จ๐ฉ๐๐ง ๐ฎ๐ง๐ญ๐ข๐ฅ ๐๐๐ซ๐๐ก ๐
๐ https://vph-conference.org/abstract-submission/
๐ย ๐๐๐๐ ๐๐๐ ๐๐๐๐
9th International Conference on the Virtual Physiological Human (VPH)
๐ September 1โ4, 2026
๐ Politecnico di Milano
๐ https://vph-conference.org

๐ ๐๐ ๐๐ซ๐ ๐ญ๐ก๐ซ๐ข๐ฅ๐ฅ๐๐ ๐ญ๐จ ๐๐ง๐ง๐จ๐ฎ๐ง๐๐ ๐จ๐ฎ๐ซ ๐ฉ๐๐ซ๐ญ๐ข๐๐ข๐ฉ๐๐ญ๐ข๐จ๐ง ๐ข๐ง ๐ญ๐ก๐ ๐๐ง๐ ๐๐ง๐ญ๐๐ซ๐ง๐๐ญ๐ข๐จ๐ง๐๐ฅ ๐๐ง๐ง๐ฎ๐๐ฅ ๐๐จ๐ง๐๐๐ซ๐๐ง๐๐ ๐จ๐ง๐๐ซ๐ญ๐ข๐๐ข๐๐ข๐๐ฅ ๐๐ง๐ญ๐๐ฅ๐ฅ๐ข๐ ๐๐ง๐๐ ๐ข๐ง ๐๐๐๐ฅ๐ญ๐ก (๐๐ข๐๐๐๐ฅ๐ญ๐ก๐๐๐๐)
๐
๐๐โ๐๐ ๐๐จ๐ฏ๐๐ฆ๐๐๐ซ ๐๐๐๐
๐ ๐๐ง๐ข๐ฏ๐๐ซ๐ฌ๐ข๐ญ๐ฒ ๐จ๐ ๐๐ฉ๐ฉ๐ฅ๐ข๐๐ ๐๐๐ข๐๐ง๐๐๐ฌ ๐๐ง๐ ๐๐ซ๐ญ๐ฌ ๐๐จ๐ซ๐ญ๐ก๐ฐ๐๐ฌ๐ญ๐๐ซ๐ง ๐๐ฐ๐ข๐ญ๐ณ๐๐ซ๐ฅ๐๐ง๐ ๐
๐๐๐ (๐๐ฎ๐ญ๐ญ๐๐ง๐ณ), ๐๐๐ฌ๐๐ฅ, ๐๐ฐ๐ข๐ญ๐ณ๐๐ซ๐ฅ๐๐ง๐
Over one and a half days, ๐๐ข๐๐๐๐ฅ๐ญ๐ก๐๐๐๐ will offer a journey into the future of healthcare, exploring how artificial intelligence is transforming diagnostics, therapeutics, and public health โ reaching the frontier of ๐๐ข๐ ๐ข๐ญ๐๐ฅ ๐ญ๐ฐ๐ข๐ง๐ฌ and ๐ฉ๐๐ซ๐ฌ๐จ๐ง๐๐ฅ๐ข๐ณ๐๐ ๐ฆ๐๐๐ข๐๐ข๐ง๐
๐ง Among the many outstanding contributions, we are proud to highlight the ๐๐๐ฒ๐ง๐จ๐ญ๐ ๐๐๐๐ญ๐ฎ๐ซ๐ by our ๐๐ซ๐จ๐ฎ๐ฉ๐๐๐๐๐๐ซ, ๐๐ซ๐จ๐. Francesco Pappalardo
(๐๐ง๐ข๐ฏ๐๐ซ๐ฌ๐ข๐ญ๐ฒ ๐จ๐ ๐๐๐ญ๐๐ง๐ข๐, ๐๐ญ๐๐ฅ๐ฒ):
๐ค โ๐๐ฆ๐ฅ๐ช๐ค๐ช๐ฏ๐ฆ ๐๐ฏ ๐๐ช๐ญ๐ช๐ค๐ฐ ๐ข๐ต ๐ต๐ฉ๐ฆ ๐๐ณ๐ฐ๐ด๐ด๐ณ๐ฐ๐ข๐ฅ๐ด: ๐๐ค๐ช๐ฆ๐ฏ๐ต๐ช๐ง๐ช๐ค ๐๐ข๐ต๐ถ๐ณ๐ช๐ต๐บ ๐ข๐ฏ๐ฅ ๐๐ฆ๐จ๐ถ๐ญ๐ข๐ต๐ฐ๐ณ๐บ ๐๐ฆ๐ข๐ฅ๐ช๐ฏ๐ฆ๐ด๐ดโ
A must-attend event for anyone involved in ๐๐ ๐ข๐ง ๐ฆ๐๐๐ข๐๐ข๐ง๐, ๐ญ๐ซ๐๐ง๐ฌ๐ฅ๐๐ญ๐ข๐จ๐ง๐๐ฅ ๐ซ๐๐ฌ๐๐๐ซ๐๐ก, ๐ซ๐๐ ๐ฎ๐ฅ๐๐ญ๐จ๐ซ๐ฒ ๐ฌ๐๐ข๐๐ง๐๐, and ๐ก๐๐๐ฅ๐ญ๐ก๐๐๐ซ๐ ๐ข๐ง๐ง๐จ๐ฏ๐๐ญ๐ข๐จ๐ง
๐ ๐๐ข๐๐ฐ ๐ญ๐ก๐ ๐๐ซ๐จ๐ ๐ซ๐๐ฆ
๐ ๐๐๐ ๐ข๐ฌ๐ญ๐๐ซ ๐ง๐จ๐ฐ to join and follow the conference
๐ ๐๐๐ ๐ข๐ฌ๐ญ๐๐ซ ๐ฐ๐ข๐ญ๐ก ๐ฒ๐จ๐ฎ๐ซ ๐ญ๐๐๐ฆ
๐ ๐
๐จ๐ซ ๐ฆ๐จ๐ซ๐ ๐ข๐ง๐๐จ๐ซ๐ฆ๐๐ญ๐ข๐จ๐ง
Join us in writing the next chapter in the history of digital medicine

๐๐ง๐ง๐จ๐ฏ๐๐ณ๐ข๐จ๐ง๐ ๐ ๐ข๐ง๐ญ๐๐ซ๐๐ข๐ฌ๐๐ข๐ฉ๐ฅ๐ข๐ง๐๐ซ๐ข๐ญร ๐ง๐๐ฅ๐ฅ๐ ๐ซ๐ข๐๐๐ซ๐๐ ๐๐ข๐จ๐ฆ๐๐๐ข๐๐
Siamo entusiasti di annunciare il workshop ๐ ๐ซ๐จ๐ง๐ญ๐ข๐๐ซ๐ฌ ๐ข๐ง ๐๐ซ๐ฎ๐ ๐๐๐ฏ๐๐ฅ๐จ๐ฉ๐ฆ๐๐ง๐ญ ๐๐ง๐ ๐ฆ๐จ๐ฅ๐๐๐ฎ๐ฅ๐๐ซ ๐ง๐๐ญ๐ฐ๐จ๐ซ๐ค unโoccasione unica per esplorare le ๐ง๐ฎ๐จ๐ฏ๐ ๐๐ซ๐จ๐ง๐ญ๐ข๐๐ซ๐ ๐๐๐ฅ๐ฅ๐ ๐ซ๐ข๐๐๐ซ๐๐ ๐๐ข๐จ๐ฆ๐๐๐ข๐๐ attraverso il dialogo tra ๐๐ข๐จ๐ฅ๐จ๐ ๐ข๐, ๐๐ข๐จ๐๐ก๐ข๐ฆ๐ข๐๐, ๐๐ก๐ข๐ฆ๐ข๐๐ ๐๐๐ซ๐ฆ๐๐๐๐ฎ๐ญ๐ข๐๐ ๐ ๐ข๐ง๐ญ๐๐ฅ๐ฅ๐ข๐ ๐๐ง๐ณ๐ ๐๐ซ๐ญ๐ข๐๐ข๐๐ข๐๐ฅ๐.
Tra i temi al centro del dibattito:
la ๐ฆ๐จ๐๐ฎ๐ฅ๐๐ณ๐ข๐จ๐ง๐ ๐๐๐ฅ๐ฅ๐ ๐๐๐ซ๐ซ๐จ๐ฉ๐ญ๐จ๐ฌ๐ข come strategia terapeutica per malattie neurodegenerative e tumorali;
Al centro dellโintervento dedicato alle โ๐๐๐ฐ ๐๐ฉ๐ฉ๐ซ๐จ๐๐๐ก ๐๐๐ญ๐ก๐จ๐๐จ๐ฅ๐จ๐ ๐ข๐๐ฌโ ci sarร la ๐ฆ๐๐๐ข๐๐ข๐ง๐ ๐ข๐ง ๐ฌ๐ข๐ฅ๐ข๐๐จ, che insieme ai modelli complessi in vitro apre nuove prospettive per una ๐ซ๐ข๐๐๐ซ๐๐ ๐๐ข๐จ๐ฆ๐๐๐ข๐๐ ๐ฉ๐ขรน ๐ฉ๐ซ๐๐๐ข๐ญ๐ญ๐ข๐ฏ๐, ๐๐ญ๐ข๐๐ ๐๐ฌ๐จ๐ฌ๐ญ๐๐ง๐ข๐๐ข๐ฅ๐, capace di migliorare la ๐ซ๐ข๐ฅ๐๐ฏ๐๐ง๐ณ๐ ๐ญ๐ซ๐๐ฌ๐ฅ๐๐ณ๐ข๐จ๐ง๐๐ฅ๐ dei risultati scientifici.
il legame tra ๐๐ก๐ข๐ฆ๐ข๐๐ ๐๐๐ซ๐ฆ๐๐๐๐ฎ๐ญ๐ข๐๐ e ๐ข๐ง๐ง๐จ๐ฏ๐๐ณ๐ข๐จ๐ง๐ ๐ญ๐๐ซ๐๐ฉ๐๐ฎ๐ญ๐ข๐๐;
lโuso di ๐๐ ๐ ๐๐ข๐ ๐ข๐ญ๐๐ฅ๐ข๐ณ๐ณ๐๐ณ๐ข๐จ๐ง๐ per scoprire nuovi composti bioattivi.
Lโiniziativa riflette pienamente la missione di ๐๐๐ ๐ยณ, che promuove ricerca e formazione avanzata in un contesto internazionale.
๐๐ ๐๐จ๐ฏ๐๐ฆ๐๐ซ๐ ๐๐๐๐
๐๐:๐๐ โ ๐๐.๐๐
๐๐ฎ๐ฅ๐ ๐๐๐ ๐ง๐ ๐๐๐ฎ๐จ๐ฅ๐ ๐๐ฎ๐ฉ๐๐ซ๐ข๐จ๐ซ๐ โ Villa San Saverio, Via Valdisavoia 9 โ Catania (CT)
Maggiori informazioni: https://safi3.it/frontiers-in-drug-development-and…/#SAFI3Universitร di Catania
Weโre excited to announce the workshop Frontiers in Drug Development and Molecular Network โ a unique opportunity to explore the new frontiers of biomedical research through dialogue between biology, biochemistry, pharmaceutical chemistry, and artificial intelligence.
Among the key topics of discussion:
Modulation of ferroptosis as a therapeutic strategy for neurodegenerative and cancer diseases;
The session on โNew Approach Methodologiesโ will focus on in silico medicine, whichโtogether with advanced in vitro modelsโopens new perspectives for a more predictive, ethical, and sustainable biomedical research, enhancing the translational relevance of scientific outcomes;
The connection between pharmaceutical chemistry and therapeutic innovation;
The use of AI and digital technologies to accelerate the discovery of new bioactive compounds.
This initiative fully reflects the mission of SAFIยณ, which promotes advanced training and interdisciplinary research in an international context.
November 27, 2025
3:00 PM โ 7:00 PM
Aula Magna, Scuola Superiore โ Villa San Saverio, Via Valdisavoia 9, Catania (CT)
More information:https://safi3.it/frontiers-in-drug-development-and…/

๐ ๐๐ซ๐๐๐ฌ๐ญ ๐๐๐ง๐๐๐ซ ๐๐ฐ๐๐ซ๐๐ง๐๐ฌ๐ฌ ๐๐จ๐ง๐ญ๐ก ๐ข๐ฌ ๐๐จ๐ฆ๐ข๐ง๐ ๐ญ๐จ ๐ ๐๐ฅ๐จ๐ฌ๐, ๐๐ฎ๐ญ ๐ญ๐ก๐ ๐๐จ๐ฆ๐ฆ๐ข๐ญ๐ฆ๐๐ง๐ญ ๐๐จ๐ง๐ญ๐ข๐ง๐ฎ๐๐ฌ ๐๐ฏ๐๐ซ๐ฒ ๐๐๐ฒ
๐๐ง ๐ฌ๐ข๐ฅ๐ข๐๐จ ๐ฆ๐๐๐ข๐๐ข๐ง๐ uses mathematical models and computer simulations to study diseases and therapies.
In breast cancer, this approach can:
โจ Predict individual drug response
โจ Optimize therapeutic combinations
โจ Reduce invasive testing
โจ Shorten research timelines
Itโs like having a patientโs โdigital twin,โ allowing different scenarios to be tested and the best strategy to be chosen
This is the path of ๐ฉ๐ซ๐๐๐ข๐ฌ๐ข๐จ๐ง ๐ฆ๐๐๐ข๐๐ข๐ง๐: more personalized, safer, faster
๐ Within this perspective, the research project was launched:
๐๐จ๐ฆ๐ฉ๐ฎ๐ญ๐๐ญ๐ข๐จ๐ง๐๐ฅ ๐๐จ๐๐๐ฅ๐ฅ๐ข๐ง๐ ๐
๐จ๐ซ ๐๐ซ๐๐๐ข๐๐ญ๐ข๐จ๐ง ๐๐ ๐๐ซ๐๐๐ญ๐ฆ๐๐ง๐ญ ๐๐ฎ๐ญ๐๐จ๐ฆ๐๐ฌ ๐๐ง ๐๐๐ซ๐ฅ๐ฒ ๐๐ญ๐๐ ๐ ๐๐ซ๐๐๐ฌ๐ญ ๐๐๐ง๐๐๐ซ ๐๐๐ญ๐ข๐๐ง๐ญ๐ฌ๐๐๐๐๐ข๐ฏ๐ข๐ง๐ ๐๐๐จ๐๐๐ฃ๐ฎ๐ฏ๐๐ง๐ญ ๐๐ก๐๐ฆ๐จ-๐๐ฆ๐ฆ๐ฎ๐ง๐จ๐ญ๐ก๐๐ซ๐๐ฉ๐ฒ: ๐ ๐๐ซ๐จ๐ฌ๐ฉ๐๐๐ญ๐ข๐ฏ๐ ๐๐๐ฌ๐๐ซ๐ฏ๐๐ญ๐ข๐จ๐ง๐๐ฅ ๐๐ญ๐ฎ๐๐ฒ
(Coordinated by Dr. Giuseppe Catanuto โ Humanitas)
๐ ๐๐ซ๐จ๐ฃ๐๐๐ญ ๐จ๐๐ฃ๐๐๐ญ๐ข๐ฏ๐๐ฌ ๐๐ง๐ ๐๐๐ฌ๐ข๐ ๐ง
๐๐ญ๐๐ซ๐ญ๐ข๐ง๐ ๐ก๐ฒ๐ฉ๐จ๐ญ๐ก๐๐ฌ๐ข๐ฌ
It is hypothesized that, using a predictive model based on UISS, it will be possible to anticipate clinical outcomes in patients with TNBC (triple-negative breast cancer) treated with chemo-immunotherapy
๐๐ซ๐ข๐ฆ๐๐ซ๐ฒ ๐จ๐๐ฃ๐๐๐ญ๐ข๐ฏ๐
โข Prediction of treatment activity based on UISS, according to pCR rates (defined as pathological stage ypT0/Tis ypN0 at the time of definitive surgery)
๐๐๐๐จ๐ง๐๐๐ซ๐ฒ ๐จ๐๐ฃ๐๐๐ญ๐ข๐ฏ๐๐ฌ
โข UISS-based prediction of survival outcomes according to Event Free Survival (EFS), defined as the time from randomization to local or distant recurrence, second primary cancer, or death
A concrete step toward ๐ฉ๐ซ๐๐๐ข๐ฌ๐ข๐จ๐ง ๐ฆ๐๐๐ข๐๐ข๐ง๐ that increasingly meets the needs of patients
UISS al Parlamento Europeo: lโeccellenza scientifica โmade in UniCTโ protagonista a Bruxelles!

Il progetto UISS โ Universal Immune System Simulator, sviluppato dal Prof. Francesco Pappalardo con il supporto del Gruppo COMBINE del Dipartimento di Scienze del Farmaco e della Salute dellโUniversitร di Catania, รจ stato recentemente presentato al Parlamento Europeo durante โExcellence in Health Scienceโ, evento promosso dal Committee on Public Health (SANT)
A rappresentarlo, la Prof.ssa Liesbet Geris (KU Leuven, Universitรฉ de Liรจge), direttrice esecutiva della Virtual Physiological Human (VPH) Initiative, che ha incluso UISS tra le innovazioni piรน avanzate nel campo della salute digitale e della medicina personalizzata.
UISS รจ oggi il modello computerizzato piรน evoluto al mondo per studiare le risposte del sistema immunitario umano a vaccini, malattie autoimmuni e terapie oncologiche. Basato su tecniche di agent-based modeling e integrando dati clinici reali, consente di:
- prevedere lโefficacia di vaccini e terapie innovative,
- ridurre tempi e costi della ricerca biomedica,
- promuovere la medicina personalizzata.
Dal 2004, UISS รจ al centro di numerosi progetti europei e internazionali e nel 2024 ha ottenuto un riconoscimento storico da parte dellโEuropean Medicines Agency (EMA) come primo approccio meccanicistico supportato a livello regolatorio โ un passo fondamentale verso lโuso dei modelli in silico per guidare le decisioni su vaccini e terapie.
โQuando vent’anni fa abbiamo iniziato a sviluppare Uiss, non immaginavamo che sarebbe arrivato a essere riconosciuto come il piรน avanzato simulatore del sistema immunitario umano e a essere presentato al Parlamento europeo.
Questo risultato รจ il frutto del lavoro di un gruppo straordinario e del sostegno del nostro dipartimento e dell’Universitร di Catania. Siamo fieri di dimostrare che l’eccellenza scientifica puรฒ nascere e crescere nel nostro territorio, portando un contributo concreto all’Europa e alla salute globale.โ
– Prof. Francesco Pappalardo
Un risultato che conferma la capacitร della ricerca italiana di incidere nel panorama scientifico internazionale e di contribuire alla costruzione di una sanitร piรน rapida, mirata e sostenibile.

๐ October is Breast Cancer Awareness Month
We at the Combine Group, Universitร di Catania Department of Drug and Health Sciences, join this awareness campaign with our contribution from the world of ๐ข๐ง ๐ฌ๐ข๐ฅ๐ข๐๐จ ๐ฆ๐๐๐ข๐๐ข๐ง๐
Throughout this month, we will share insights, data, and perspectives on how research and new technologies can support prevention and treatment.
๐กPrevention starts with information
๐ Follow us on LinkedIn Combine Group

๐ ๐๐๐ ๐ ๐ข๐จ ๐๐๐๐ โ ๐๐๐๐๐๐ ๐๐๐ ๐๐ข๐ฉ๐๐ซ๐ญ๐ข๐ฆ๐๐ง๐ญ๐จ ๐๐ข ๐๐๐ข๐๐ง๐ณ๐ ๐๐๐ฅ ๐
๐๐ซ๐ฆ๐๐๐จ ๐ ๐๐๐ฅ๐ฅ๐ ๐๐๐ฅ๐ฎ๐ญ๐, ๐๐ง๐ข๐ฏ๐๐ซ๐ฌ๐ข๐ญร ๐๐ข๐๐๐ญ๐๐ง๐ข๐
Una giornata ricca di confronto e innovazione quella del Pharma Day, che ha visto protagonisti studenti, docenti e ricercatori del Dipartimento di Scienze del Farmaco e della Salute dellโ Universitร di Catania
Anche il ๐๐จ๐ฆ๐๐ข๐ง๐ ๐๐ซ๐จ๐ฎ๐ฉ ha avuto il piacere di presentare una serie di ๐ฉ๐จ๐ฌ๐ญ๐๐ซ ๐ฌ๐๐ข๐๐ง๐ญ๐ข๐๐ข๐๐ข, illustrando le attivitร di ricerca in ambito farmacologico e computazionale, con un focus su ๐ฆ๐จ๐๐๐ฅ๐ฅ๐ข ๐ฉ๐ซ๐๐๐ข๐ญ๐ญ๐ข๐ฏ๐ข e ๐ฌ๐ข๐ฆ๐ฎ๐ฅ๐๐ณ๐ข๐จ๐ง๐ข ๐๐ฏ๐๐ง๐ณ๐๐ญ๐.
Nel pomeriggio si รจ tenuto un intervento incentrato sul ๐ฌ๐ข๐ฆ๐ฎ๐ฅ๐๐ญ๐จ๐ซ๐ ๐๐๐๐ (๐๐ง๐ข๐ฏ๐๐ซ๐ฌ๐๐ฅ ๐๐ฆ๐ฆ๐ฎ๐ง๐ ๐๐ฒ๐ฌ๐ญ๐๐ฆ๐๐ข๐ฆ๐ฎ๐ฅ๐๐ญ๐จ๐ซ), sviluppato allโinterno del Combine Group. Durante la presentazione sono state illustrate le sue potenzialitร come strumento avanzato per la ๐ซ๐ข๐๐๐ซ๐๐ ๐ฉ๐ซ๐๐๐ฅ๐ข๐ง๐ข๐๐ ๐ ๐๐ฅ๐ข๐ง๐ข๐๐, in particolare nel contesto della ๐ฆ๐๐๐ข๐๐ข๐ง๐ ๐ฉ๐๐ซ๐ฌ๐จ๐ง๐๐ฅ๐ข๐ณ๐ณ๐๐ญ๐ e della valutazione di ๐ฌ๐ญ๐ซ๐๐ญ๐๐ ๐ข๐ ๐ญ๐๐ซ๐๐ฉ๐๐ฎ๐ญ๐ข๐๐ก๐ ๐ข๐ง๐ง๐จ๐ฏ๐๐ญ๐ข๐ฏ๐.
Tra i punti salienti, รจ stato evidenziato che ๐ฎ๐ง๐ ๐ฌ๐จ๐ฅ๐ฎ๐ณ๐ข๐จ๐ง๐ ๐๐๐๐ ๐๐๐๐ข๐๐๐ญ๐ ๐๐ฅ๐ฅ๐ ๐ญ๐ฎ๐๐๐ซ๐๐จ๐ฅ๐จ๐ฌ๐ข (๐๐๐๐-๐๐) ๐ก๐ ๐ซ๐ข๐๐๐ฏ๐ฎ๐ญ๐จ ๐ฎ๐ง๐ ๐ฅ๐๐ญ๐ญ๐๐ซ๐ ๐๐ข ๐ฌ๐ฎ๐ฉ๐ฉ๐จ๐ซ๐ญ๐จ ๐๐ ๐ฉ๐๐ซ๐ญ๐ ๐๐๐ฅ๐ฅโ๐๐๐ (๐๐ฎ๐ซ๐จ๐ฉ๐๐๐ง ๐๐๐๐ข๐๐ข๐ง๐๐ฌ ๐๐ ๐๐ง๐๐ฒ), riconoscendone il valore scientifico e applicativo.
Un sentito ringraziamento a tutti i partecipanti per aver contribuito a rendere il Pharma Day unโoccasione di ๐๐ซ๐๐ฌ๐๐ข๐ญ๐, ๐๐จ๐ง๐๐ข๐ฏ๐ข๐ฌ๐ข๐จ๐ง๐ ๐ ๐ข๐ฌ๐ฉ๐ข๐ซ๐๐ณ๐ข๐จ๐ง๐ ๐ฌ๐๐ข๐๐ง๐ญ๐ข๐๐ข๐๐.

Prof Francesco Pappalardo Explores Innovative In Silico Approaches at Biomathematics Workshop

The workshop “New Trends in Biomathematics – Applications in Oncology and Immunology” was held today, June 21, 2024, at Universitร degli Studi Mediterranea di Reggio Calabria. This event brought together experts and enthusiasts from various fields to discuss the latest advancements in the application of mathematical models to medical research.
๐๏ธ Presentations by Prof. Francesco Pappalardo:
Beyond the Data: Computational Modeling as a Tool in Oncology and Immunology
Simulating to Predict: Computational Models in Infectious Diseases
Prof. Francesco Pappalardo’s presentations highlighted the transformative potential of in silico medicine, a field that uses computational models to simulate biological processes. These techniques promise to revolutionize healthcare by reducing the costs and time required for drug development.
๐น Key Insights:
In Silico Medicine: Prof. Pappalardo illustrated how computational modeling can enhance our understanding of disease mechanisms, optimize drug development, and personalize treatments.
Revolutionizing Healthcare: By simulating clinical trials and predicting treatment outcomes, in silico methods offer a more efficient and ethical approach to medical research.
The workshop aimed to review the state of the art in mathematics applied to oncology and immunology, identifying emerging trends and strategies to advance the field. This gathering was of significant interest not only to experts in mathematical modeling and bioinformatics but also to doctors, biologists, and researchers in life and health sciences.

๐ฌ The event underscored the importance of interdisciplinary collaboration in pushing the boundaries of medical research. By integrating computational techniques with traditional medical practices, we can look forward to a future where healthcare is more precise, efficient, and personalized.
Stay tuned for more updates on the latest trends and breakthroughs in biomathematics and its applications in medicine.
Join Us for an Exciting Event on Pharmaceutical Research!
On Wednesday, May 15th, at 12:00 PM, in Classroom F (Building 2, University City), don’t miss the chance to meet Professor Francesco Pappalardo and Professor Giulia Russo from the DSFS! ๐
๐ Event Theme: “Impact of In Silico Trials on the Pharmaceutical World: Regulatory Challenges and Opportunities for Pharmaceutical and Health Sciences Students.” ๐
๐ง Discover the revolutionary Universal Immune System Simulator (UISS), developed by the Combine Group. This cutting-edge computational framework promises to transform the pharmaceutical industry! ๐ก
From predicting vaccination strategies to identifying molecular targets to overcome drug resistance, UISS offers a broad spectrum of possibilities that will revolutionize the future of pharmaceutical research. ๐
๐ฉโ๐ฌ Students, especially those in the final years of their degree programs, are encouraged to attend and immerse themselves in this field of excellence from our department. Donโt miss out! ๐
PharmaceuticalResearch #InSilico #UISS #DSFS #UniversityOfCatania

First annual meeting (Switzerland, 2024)
Welcome to our latest update on the groundbreaking initiatives in tuberculosis research! As we delve into the world of tuberculosis consortium partnerships, we are excited to share the progress made in developing novel therapeutic options, improving outcomes, and preventing relapse. Our collaborative efforts aim to bring about transformative changes in tuberculosis treatment, with a focus on shortening treatment duration.


โ In Vivo Evaluation of Immunotherapies
A major focus of our research involves the in vivo evaluation of the most promising immunotherapies. By combining these therapies with traditional approaches like chemotherapy or therapeutic vaccines, we aim to enhance their efficacy and potentially shorten the overall treatment duration. This approach holds great promise in revolutionizing tuberculosis treatment protocols.
โ In Silico Modeling for Preclinical Progression
Harnessing the power of technology, our consortium employs in silico modeling to facilitate both in vitro and in vivo preclinical progression. This cutting-edge approach allows us to simulate and predict the therapeutic effects of potential treatments in the clinic. By utilizing advanced computational methods, we can streamline the research process, saving valuable time and resources.

One of the Goals: Develop Novel Therapeutic Options
Our consortium is committed to pushing the boundaries of tuberculosis research by developing innovative therapeutic options. The goal is to create treatments that not only effectively combat the disease but also have the potential to significantly reduce the duration of treatment. By leveraging the collective expertise of our partners, we are exploring new avenues for drug development and testing.
โ Improve Outcomes and Prevent Relapse
Achieving better outcomes for tuberculosis patients is at the forefront of our collaborative efforts. We are dedicated to identifying strategies that not only cure the infection but also prevent relapses. Our consortium recognizes the importance of sustained recovery, and our research is geared towards finding solutions that ensure long-term success in tuberculosis treatment.


โ Reflecting on Achievements and Future Goals
As we come together to discuss the accomplishments of the past year, we express our gratitude for the opportunity to collaborate and make significant strides in tuberculosis research. Our consortium’s dedication to advancing the field is evident in the milestones achieved, from the development of novel therapeutic options to the successful in vivo evaluation of immunotherapies.
Looking ahead, our future goals include expanding our collaborative efforts, integrating new research findings, and continuously striving for innovative solutions to combat tuberculosis. We are excited about the possibilities that lie ahead and are confident that our collective endeavors will contribute to the global fight against this infectious disease.
In conclusion, our tuberculosis consortium is making significant progress in reshaping the landscape of tuberculosis research. By fostering collaboration, embracing innovation, and reflecting on our achievements, we are committed to bringing about positive change in the lives of those affected by tuberculosis. Together, we are on the path to transforming the future of tuberculosis treatment. Thank you for your ongoing support and partnership in this important endeavor.
Pint of Science 2023

ร possibile creare una replica digitale di un paziente, in grado di anticipare le variazioni nel suo stato di salute e fornire un valido supporto decisionale per la gestione clinica? Grazie agli avanzamenti nelle tecnologie informatiche di ultima generazione, oggi possiamo integrare e analizzare tutte le informazioni disponibili per un singolo paziente, consentendoci di predire l’andamento della sua salute in specifiche condizioni. Il Professor Francesco Pappalardo approfondirร questo argomento e altri aspetti affascinanti, il tutto in un’atmosfera informale, davanti a una piacevole pinta di birra
Sharper Night
Catania ha recentemente celebrato e sottolineato l’importanza della ricerca attraverso la partecipazione alla Notte Europea dei Ricercatori. La cittร ha ideato un ricco programma che abbraccia una vasta gamma di temi, spaziando dalla ricerca di base alle applicazioni tecnologiche in campi diversificati. L’interdisciplinarietร e le sfide per il futuro hanno guidato l’intero programma, creando un filo conduttore che ha accentuato la diversitร e la portata delle iniziative presentate durante l’evento.
Event link: https://www.sharper-night.it/evento/conferenza-universita-imprenditoriale/

4 April 2023 – Les Diablerets (Switzerland)

UISS, il paziente virtuale โ Radio24 (IlSole24Ore)
Sono questi gli obiettivi cui punta un gruppo di ricercatori dell’Universitร di Catania con Uiss, il paziente virtuale. Uiss sta per Universal Immune System Simulator, รจ frutto di un quindicennio di lavoro degli scienziati catanesi e rientra a pieno titolo in quel settore della medicina computazionale.
Come dice il nome, parliamo di un software che รจ in grado di simulare il comportamento del sistema immunitario di un individuo (e anche di gruppi di individui, ognuno con caratteristiche immunitarie diverse) di fronte all’aggressione di un patogeno e in presenza di un farmaco. Giร sperimentato su varie patologie, oggi viene applicato, non sorprendentemente, anche alla Covid.
Ospite Francesco Pappalardo, Professor in Computer Science del Dipartimento di Scienze del Farmaco dell’Universitร di Catania.
COVID-19, la ricerca accende i riflettori sull’argomento vaccini โ Radio Fantastica
Su Radio Fantastica รจ intervenuto il Prof. Francesco Pappalardo docente di Informatica dell’Universitร degli Studi di Catania.

