Department of Drug and Health Sciences, V.le A. Doria, 6, 95125 Catania, Italy
Office: +39 095/7384223
combine@combine-group.org

Events

๐Ÿ“ขย ๐‚๐š๐ฅ๐ฅ ๐Ÿ๐จ๐ซ ๐€๐›๐ฌ๐ญ๐ซ๐š๐œ๐ญ๐ฌ โ€“ ๐•๐๐‡ ๐Ÿ๐ŸŽ๐Ÿ๐Ÿ” | ๐๐Ž๐– ๐Ž๐๐„๐!

We are excited to share that ourย Group Leaderย Prof. Francesco Pappalardo serve asย Chair of the Track โ€œ๐˜Š๐˜ฐ๐˜ฎ๐˜ฑ๐˜ถ๐˜ต๐˜ข๐˜ต๐˜ช๐˜ฐ๐˜ฏ๐˜ข๐˜ญ ๐˜ข๐˜ฏ๐˜ฅ ๐˜ˆ๐˜-๐˜ฅ๐˜ณ๐˜ช๐˜ท๐˜ฆ๐˜ฏ ๐˜‹๐˜ณ๐˜ถ๐˜จ ๐˜‹๐˜ฆ๐˜ญ๐˜ช๐˜ท๐˜ฆ๐˜ณ๐˜บ ๐˜ข๐˜ฏ๐˜ฅ ๐˜‹๐˜ฆ๐˜ด๐˜ช๐˜จ๐˜ฏโ€ย at theย ๐Ÿ—๐ญ๐ก ๐ˆ๐ง๐ญ๐ž๐ซ๐ง๐š๐ญ๐ข๐จ๐ง๐š๐ฅ ๐‚๐จ๐ง๐Ÿ๐ž๐ซ๐ž๐ง๐œ๐ž ๐จ๐ง ๐ญ๐ก๐ž ๐•๐ข๐ซ๐ญ๐ฎ๐š๐ฅ ๐๐ก๐ฒ๐ฌ๐ข๐จ๐ฅ๐จ๐ ๐ข๐œ๐š๐ฅ ๐‡๐ฎ๐ฆ๐š๐ง (๐•๐๐‡ ๐Ÿ๐ŸŽ๐Ÿ๐Ÿ”)

This is a fantastic opportunity to contribute and engage in discussions on computational and AI-driven approaches in drug delivery and drug design, within one of the leading conferences in the field

๐Ÿ“ย ๐€๐›๐ฌ๐ญ๐ซ๐š๐œ๐ญ ๐ฌ๐ฎ๐›๐ฆ๐ข๐ฌ๐ฌ๐ข๐จ๐ง๐ฌ ๐š๐ซ๐ž ๐ง๐จ๐ฐ ๐จ๐ฉ๐ž๐ง ๐ฎ๐ง๐ญ๐ข๐ฅ ๐Œ๐š๐ซ๐œ๐ก ๐Ÿ
๐Ÿ”— https://vph-conference.org/abstract-submission/

๐Ÿ“Œย ๐’๐€๐•๐„ ๐“๐‡๐„ ๐ƒ๐€๐“๐„
9th International Conference on the Virtual Physiological Human (VPH)
๐Ÿ—“ September 1โ€“4, 2026
๐Ÿ“ Politecnico di Milano
๐Ÿ”— https://vph-conference.org


๐Ÿš€ ๐–๐ž ๐š๐ซ๐ž ๐ญ๐ก๐ซ๐ข๐ฅ๐ฅ๐ž๐ ๐ญ๐จ ๐š๐ง๐ง๐จ๐ฎ๐ง๐œ๐ž ๐จ๐ฎ๐ซ ๐ฉ๐š๐ซ๐ญ๐ข๐œ๐ข๐ฉ๐š๐ญ๐ข๐จ๐ง ๐ข๐ง ๐ญ๐ก๐ž ๐Ÿ๐ง๐ ๐ˆ๐ง๐ญ๐ž๐ซ๐ง๐š๐ญ๐ข๐จ๐ง๐š๐ฅ ๐€๐ง๐ง๐ฎ๐š๐ฅ ๐‚๐จ๐ง๐Ÿ๐ž๐ซ๐ž๐ง๐œ๐ž ๐จ๐ง๐€๐ซ๐ญ๐ข๐Ÿ๐ข๐œ๐ข๐š๐ฅ ๐ˆ๐ง๐ญ๐ž๐ฅ๐ฅ๐ข๐ ๐ž๐ง๐œ๐ž ๐ข๐ง ๐‡๐ž๐š๐ฅ๐ญ๐ก (๐š๐ข๐‡๐ž๐š๐ฅ๐ญ๐ก๐Ÿ๐ŸŽ๐Ÿ๐Ÿ“)
๐Ÿ“… ๐Ÿ๐ŸŽโ€“๐Ÿ๐Ÿ ๐๐จ๐ฏ๐ž๐ฆ๐›๐ž๐ซ ๐Ÿ๐ŸŽ๐Ÿ๐Ÿ“
๐Ÿ“ ๐”๐ง๐ข๐ฏ๐ž๐ซ๐ฌ๐ข๐ญ๐ฒ ๐จ๐Ÿ ๐€๐ฉ๐ฉ๐ฅ๐ข๐ž๐ ๐’๐œ๐ข๐ž๐ง๐œ๐ž๐ฌ ๐š๐ง๐ ๐€๐ซ๐ญ๐ฌ ๐๐จ๐ซ๐ญ๐ก๐ฐ๐ž๐ฌ๐ญ๐ž๐ซ๐ง ๐’๐ฐ๐ข๐ญ๐ณ๐ž๐ซ๐ฅ๐š๐ง๐ ๐…๐‡๐๐– (๐Œ๐ฎ๐ญ๐ญ๐ž๐ง๐ณ), ๐๐š๐ฌ๐ž๐ฅ, ๐’๐ฐ๐ข๐ญ๐ณ๐ž๐ซ๐ฅ๐š๐ง๐

Over one and a half days, ๐š๐ข๐‡๐ž๐š๐ฅ๐ญ๐ก๐Ÿ๐ŸŽ๐Ÿ๐Ÿ“ will offer a journey into the future of healthcare, exploring how artificial intelligence is transforming diagnostics, therapeutics, and public health โ€” reaching the frontier of ๐๐ข๐ ๐ข๐ญ๐š๐ฅ ๐ญ๐ฐ๐ข๐ง๐ฌ and ๐ฉ๐ž๐ซ๐ฌ๐จ๐ง๐š๐ฅ๐ข๐ณ๐ž๐ ๐ฆ๐ž๐๐ข๐œ๐ข๐ง๐ž

๐Ÿง  Among the many outstanding contributions, we are proud to highlight the ๐Š๐ž๐ฒ๐ง๐จ๐ญ๐ž ๐‹๐ž๐œ๐ญ๐ฎ๐ซ๐ž by our ๐†๐ซ๐จ๐ฎ๐ฉ๐‹๐ž๐š๐๐ž๐ซ, ๐๐ซ๐จ๐Ÿ. Francesco Pappalardo
(๐”๐ง๐ข๐ฏ๐ž๐ซ๐ฌ๐ข๐ญ๐ฒ ๐จ๐Ÿ ๐‚๐š๐ญ๐š๐ง๐ข๐š, ๐ˆ๐ญ๐š๐ฅ๐ฒ):
๐ŸŽค โ€œ๐˜”๐˜ฆ๐˜ฅ๐˜ช๐˜ค๐˜ช๐˜ฏ๐˜ฆ ๐˜๐˜ฏ ๐˜š๐˜ช๐˜ญ๐˜ช๐˜ค๐˜ฐ ๐˜ข๐˜ต ๐˜ต๐˜ฉ๐˜ฆ ๐˜Š๐˜ณ๐˜ฐ๐˜ด๐˜ด๐˜ณ๐˜ฐ๐˜ข๐˜ฅ๐˜ด: ๐˜š๐˜ค๐˜ช๐˜ฆ๐˜ฏ๐˜ต๐˜ช๐˜ง๐˜ช๐˜ค ๐˜”๐˜ข๐˜ต๐˜ถ๐˜ณ๐˜ช๐˜ต๐˜บ ๐˜ข๐˜ฏ๐˜ฅ ๐˜™๐˜ฆ๐˜จ๐˜ถ๐˜ญ๐˜ข๐˜ต๐˜ฐ๐˜ณ๐˜บ ๐˜™๐˜ฆ๐˜ข๐˜ฅ๐˜ช๐˜ฏ๐˜ฆ๐˜ด๐˜ดโ€

A must-attend event for anyone involved in ๐€๐ˆ ๐ข๐ง ๐ฆ๐ž๐๐ข๐œ๐ข๐ง๐ž, ๐ญ๐ซ๐š๐ง๐ฌ๐ฅ๐š๐ญ๐ข๐จ๐ง๐š๐ฅ ๐ซ๐ž๐ฌ๐ž๐š๐ซ๐œ๐ก, ๐ซ๐ž๐ ๐ฎ๐ฅ๐š๐ญ๐จ๐ซ๐ฒ ๐ฌ๐œ๐ข๐ž๐ง๐œ๐ž, and ๐ก๐ž๐š๐ฅ๐ญ๐ก๐œ๐š๐ซ๐ž ๐ข๐ง๐ง๐จ๐ฏ๐š๐ญ๐ข๐จ๐ง

๐Ÿ‘‰ ๐•๐ข๐ž๐ฐ ๐ญ๐ก๐ž ๐๐ซ๐จ๐ ๐ซ๐š๐ฆ
๐Ÿ‘‰ ๐‘๐ž๐ ๐ข๐ฌ๐ญ๐ž๐ซ ๐ง๐จ๐ฐ to join and follow the conference
๐Ÿ‘‰ ๐‘๐ž๐ ๐ข๐ฌ๐ญ๐ž๐ซ ๐ฐ๐ข๐ญ๐ก ๐ฒ๐จ๐ฎ๐ซ ๐ญ๐ž๐š๐ฆ
๐Ÿ‘‰ ๐…๐จ๐ซ ๐ฆ๐จ๐ซ๐ž ๐ข๐ง๐Ÿ๐จ๐ซ๐ฆ๐š๐ญ๐ข๐จ๐ง

Join us in writing the next chapter in the history of digital medicine


๐ˆ๐ง๐ง๐จ๐ฏ๐š๐ณ๐ข๐จ๐ง๐ž ๐ž ๐ข๐ง๐ญ๐ž๐ซ๐๐ข๐ฌ๐œ๐ข๐ฉ๐ฅ๐ข๐ง๐š๐ซ๐ข๐ญร  ๐ง๐ž๐ฅ๐ฅ๐š ๐ซ๐ข๐œ๐ž๐ซ๐œ๐š ๐›๐ข๐จ๐ฆ๐ž๐๐ข๐œ๐š

Siamo entusiasti di annunciare il workshop ๐…๐ซ๐จ๐ง๐ญ๐ข๐ž๐ซ๐ฌ ๐ข๐ง ๐๐ซ๐ฎ๐  ๐๐ž๐ฏ๐ž๐ฅ๐จ๐ฉ๐ฆ๐ž๐ง๐ญ ๐š๐ง๐ ๐ฆ๐จ๐ฅ๐ž๐œ๐ฎ๐ฅ๐š๐ซ ๐ง๐ž๐ญ๐ฐ๐จ๐ซ๐ค unโ€™occasione unica per esplorare le ๐ง๐ฎ๐จ๐ฏ๐ž ๐Ÿ๐ซ๐จ๐ง๐ญ๐ข๐ž๐ซ๐ž ๐๐ž๐ฅ๐ฅ๐š ๐ซ๐ข๐œ๐ž๐ซ๐œ๐š ๐›๐ข๐จ๐ฆ๐ž๐๐ข๐œ๐š attraverso il dialogo tra ๐›๐ข๐จ๐ฅ๐จ๐ ๐ข๐š, ๐›๐ข๐จ๐œ๐ก๐ข๐ฆ๐ข๐œ๐š, ๐œ๐ก๐ข๐ฆ๐ข๐œ๐š ๐Ÿ๐š๐ซ๐ฆ๐š๐œ๐ž๐ฎ๐ญ๐ข๐œ๐š ๐ž ๐ข๐ง๐ญ๐ž๐ฅ๐ฅ๐ข๐ ๐ž๐ง๐ณ๐š ๐š๐ซ๐ญ๐ข๐Ÿ๐ข๐œ๐ข๐š๐ฅ๐ž.

Tra i temi al centro del dibattito:

๐Ÿง  la ๐ฆ๐จ๐๐ฎ๐ฅ๐š๐ณ๐ข๐จ๐ง๐ž ๐๐ž๐ฅ๐ฅ๐š ๐Ÿ๐ž๐ซ๐ซ๐จ๐ฉ๐ญ๐จ๐ฌ๐ข come strategia terapeutica per malattie neurodegenerative e tumorali;

๐Ÿงช Al centro dellโ€™intervento dedicato alle โ€œ๐๐ž๐ฐ ๐€๐ฉ๐ฉ๐ซ๐จ๐š๐œ๐ก ๐Œ๐ž๐ญ๐ก๐จ๐๐จ๐ฅ๐จ๐ ๐ข๐ž๐ฌโ€ ci sarร  la ๐ฆ๐ž๐๐ข๐œ๐ข๐ง๐š ๐ข๐ง ๐ฌ๐ข๐ฅ๐ข๐œ๐จ, che insieme ai modelli complessi in vitro apre nuove prospettive per una ๐ซ๐ข๐œ๐ž๐ซ๐œ๐š ๐›๐ข๐จ๐ฆ๐ž๐๐ข๐œ๐š ๐ฉ๐ขรน ๐ฉ๐ซ๐ž๐๐ข๐ญ๐ญ๐ข๐ฏ๐š, ๐ž๐ญ๐ข๐œ๐š ๐ž๐ฌ๐จ๐ฌ๐ญ๐ž๐ง๐ข๐›๐ข๐ฅ๐ž, capace di migliorare la ๐ซ๐ข๐ฅ๐ž๐ฏ๐š๐ง๐ณ๐š ๐ญ๐ซ๐š๐ฌ๐ฅ๐š๐ณ๐ข๐จ๐ง๐š๐ฅ๐ž dei risultati scientifici.

๐Ÿ’Š il legame tra ๐œ๐ก๐ข๐ฆ๐ข๐œ๐š ๐Ÿ๐š๐ซ๐ฆ๐š๐œ๐ž๐ฎ๐ญ๐ข๐œ๐š e ๐ข๐ง๐ง๐จ๐ฏ๐š๐ณ๐ข๐จ๐ง๐ž ๐ญ๐ž๐ซ๐š๐ฉ๐ž๐ฎ๐ญ๐ข๐œ๐š;

๐Ÿค– lโ€™uso di ๐€๐ˆ ๐ž ๐๐ข๐ ๐ข๐ญ๐š๐ฅ๐ข๐ณ๐ณ๐š๐ณ๐ข๐จ๐ง๐ž per scoprire nuovi composti bioattivi.

Lโ€™iniziativa riflette pienamente la missione di ๐’๐€๐…๐ˆยณ, che promuove ricerca e formazione avanzata in un contesto internazionale.

๐Ÿ“… ๐Ÿ๐Ÿ• ๐๐จ๐ฏ๐ž๐ฆ๐›๐ซ๐ž ๐Ÿ๐ŸŽ๐Ÿ๐Ÿ“
๐Ÿ•ฐ๏ธ ๐Ÿ๐Ÿ“:๐ŸŽ๐ŸŽ โ€“ ๐Ÿ๐Ÿ—.๐ŸŽ๐ŸŽ
๐Ÿ“ ๐€๐ฎ๐ฅ๐š ๐Œ๐š๐ ๐ง๐š ๐’๐œ๐ฎ๐จ๐ฅ๐š ๐’๐ฎ๐ฉ๐ž๐ซ๐ข๐จ๐ซ๐ž โ€“ Villa San Saverio, Via Valdisavoia 9 โ€“ Catania (CT)

๐Ÿ”— Maggiori informazioni: https://safi3.it/frontiers-in-drug-development-and…/#SAFI3Universitร  di Catania

Weโ€™re excited to announce the workshop Frontiers in Drug Development and Molecular Network โ€” a unique opportunity to explore the new frontiers of biomedical research through dialogue between biology, biochemistry, pharmaceutical chemistry, and artificial intelligence.

Among the key topics of discussion:

๐Ÿง  Modulation of ferroptosis as a therapeutic strategy for neurodegenerative and cancer diseases;

๐Ÿงช The session on โ€œNew Approach Methodologiesโ€ will focus on in silico medicine, whichโ€”together with advanced in vitro modelsโ€”opens new perspectives for a more predictive, ethical, and sustainable biomedical research, enhancing the translational relevance of scientific outcomes;

๐Ÿ’Š The connection between pharmaceutical chemistry and therapeutic innovation;

๐Ÿค– The use of AI and digital technologies to accelerate the discovery of new bioactive compounds.

This initiative fully reflects the mission of SAFIยณ, which promotes advanced training and interdisciplinary research in an international context.

๐Ÿ“… November 27, 2025
๐Ÿ•ฐ๏ธ 3:00 PM โ€“ 7:00 PM
๐Ÿ“ Aula Magna, Scuola Superiore โ€“ Villa San Saverio, Via Valdisavoia 9, Catania (CT)

๐Ÿ”— More information:https://safi3.it/frontiers-in-drug-development-and…/


๐ŸŽ€ ๐๐ซ๐ž๐š๐ฌ๐ญ ๐‚๐š๐ง๐œ๐ž๐ซ ๐€๐ฐ๐š๐ซ๐ž๐ง๐ž๐ฌ๐ฌ ๐Œ๐จ๐ง๐ญ๐ก ๐ข๐ฌ ๐œ๐จ๐ฆ๐ข๐ง๐  ๐ญ๐จ ๐š ๐œ๐ฅ๐จ๐ฌ๐ž, ๐›๐ฎ๐ญ ๐ญ๐ก๐ž ๐œ๐จ๐ฆ๐ฆ๐ข๐ญ๐ฆ๐ž๐ง๐ญ ๐œ๐จ๐ง๐ญ๐ข๐ง๐ฎ๐ž๐ฌ ๐ž๐ฏ๐ž๐ซ๐ฒ ๐๐š๐ฒ
๐ˆ๐ง ๐ฌ๐ข๐ฅ๐ข๐œ๐จ ๐ฆ๐ž๐๐ข๐œ๐ข๐ง๐ž uses mathematical models and computer simulations to study diseases and therapies.
In breast cancer, this approach can:
โœจ Predict individual drug response
โœจ Optimize therapeutic combinations
โœจ Reduce invasive testing
โœจ Shorten research timelines

Itโ€™s like having a patientโ€™s โ€œdigital twin,โ€ allowing different scenarios to be tested and the best strategy to be chosen

This is the path of ๐ฉ๐ซ๐ž๐œ๐ข๐ฌ๐ข๐จ๐ง ๐ฆ๐ž๐๐ข๐œ๐ข๐ง๐ž: more personalized, safer, faster

๐Ÿ“Œ Within this perspective, the research project was launched:
๐‚๐จ๐ฆ๐ฉ๐ฎ๐ญ๐š๐ญ๐ข๐จ๐ง๐š๐ฅ ๐Œ๐จ๐๐ž๐ฅ๐ฅ๐ข๐ง๐  ๐…๐จ๐ซ ๐๐ซ๐ž๐๐ข๐œ๐ญ๐ข๐จ๐ง ๐Ž๐Ÿ ๐“๐ซ๐ž๐š๐ญ๐ฆ๐ž๐ง๐ญ ๐Ž๐ฎ๐ญ๐œ๐จ๐ฆ๐ž๐ฌ ๐ˆ๐ง ๐„๐š๐ซ๐ฅ๐ฒ ๐’๐ญ๐š๐ ๐ž ๐๐ซ๐ž๐š๐ฌ๐ญ ๐‚๐š๐ง๐œ๐ž๐ซ ๐๐š๐ญ๐ข๐ž๐ง๐ญ๐ฌ๐‘๐ž๐œ๐ž๐ข๐ฏ๐ข๐ง๐  ๐๐ž๐จ๐š๐๐ฃ๐ฎ๐ฏ๐š๐ง๐ญ ๐‚๐ก๐ž๐ฆ๐จ-๐ˆ๐ฆ๐ฆ๐ฎ๐ง๐จ๐ญ๐ก๐ž๐ซ๐š๐ฉ๐ฒ: ๐€ ๐๐ซ๐จ๐ฌ๐ฉ๐ž๐œ๐ญ๐ข๐ฏ๐ž ๐Ž๐›๐ฌ๐ž๐ซ๐ฏ๐š๐ญ๐ข๐จ๐ง๐š๐ฅ ๐’๐ญ๐ฎ๐๐ฒ
(Coordinated by Dr. Giuseppe Catanuto โ€“ Humanitas)

๐Ÿ‘‰ ๐๐ซ๐จ๐ฃ๐ž๐œ๐ญ ๐จ๐›๐ฃ๐ž๐œ๐ญ๐ข๐ฏ๐ž๐ฌ ๐š๐ง๐ ๐๐ž๐ฌ๐ข๐ ๐ง

๐’๐ญ๐š๐ซ๐ญ๐ข๐ง๐  ๐ก๐ฒ๐ฉ๐จ๐ญ๐ก๐ž๐ฌ๐ข๐ฌ
It is hypothesized that, using a predictive model based on UISS, it will be possible to anticipate clinical outcomes in patients with TNBC (triple-negative breast cancer) treated with chemo-immunotherapy

๐๐ซ๐ข๐ฆ๐š๐ซ๐ฒ ๐จ๐›๐ฃ๐ž๐œ๐ญ๐ข๐ฏ๐ž
โ€ข Prediction of treatment activity based on UISS, according to pCR rates (defined as pathological stage ypT0/Tis ypN0 at the time of definitive surgery)

๐’๐ž๐œ๐จ๐ง๐๐š๐ซ๐ฒ ๐จ๐›๐ฃ๐ž๐œ๐ญ๐ข๐ฏ๐ž๐ฌ
โ€ข UISS-based prediction of survival outcomes according to Event Free Survival (EFS), defined as the time from randomization to local or distant recurrence, second primary cancer, or death

A concrete step toward ๐ฉ๐ซ๐ž๐œ๐ข๐ฌ๐ข๐จ๐ง ๐ฆ๐ž๐๐ข๐œ๐ข๐ง๐ž that increasingly meets the needs of patients


 UISS al Parlamento Europeo: lโ€™eccellenza scientifica โ€œmade in UniCTโ€ protagonista a Bruxelles! 

Titolo dellโ€™articolo pubblicato dal quotidiano โ€œLa Siciliaโ€, che ha raccontato questo importante riconoscimento per il nostro gruppo di ricerca.

Il progetto UISS โ€“ Universal Immune System Simulator, sviluppato dal Prof. Francesco Pappalardo con il supporto del Gruppo COMBINE del Dipartimento di Scienze del Farmaco e della Salute dellโ€™Universitร  di Catania, รจ stato recentemente presentato al Parlamento Europeo durante โ€œExcellence in Health Scienceโ€, evento promosso dal Committee on Public Health (SANT)

A rappresentarlo, la Prof.ssa Liesbet Geris (KU Leuven, Universitรฉ de Liรจge), direttrice esecutiva della Virtual Physiological Human (VPH) Initiative, che ha incluso UISS tra le innovazioni piรน avanzate nel campo della salute digitale e della medicina personalizzata.

UISS รจ oggi il modello computerizzato piรน evoluto al mondo per studiare le risposte del sistema immunitario umano a vaccini, malattie autoimmuni e terapie oncologiche. Basato su tecniche di agent-based modeling e integrando dati clinici reali, consente di:

  • prevedere lโ€™efficacia di vaccini e terapie innovative,
  • ridurre tempi e costi della ricerca biomedica,
  • promuovere la medicina personalizzata.

Dal 2004, UISS รจ al centro di numerosi progetti europei e internazionali e nel 2024 ha ottenuto un riconoscimento storico da parte dellโ€™European Medicines Agency (EMA) come primo approccio meccanicistico supportato a livello regolatorio โ€” un passo fondamentale verso lโ€™uso dei modelli in silico per guidare le decisioni su vaccini e terapie.

โ€œQuando vent’anni fa abbiamo iniziato a sviluppare Uiss, non immaginavamo che sarebbe arrivato a essere riconosciuto come il piรน avanzato simulatore del sistema immunitario umano e a essere presentato al Parlamento europeo.
Questo risultato รจ il frutto del lavoro di un gruppo straordinario e del sostegno del nostro dipartimento e dell’Universitร  di Catania. Siamo fieri di dimostrare che l’eccellenza scientifica puรฒ nascere e crescere nel nostro territorio, portando un contributo concreto all’Europa e alla salute globale.โ€
– Prof. Francesco Pappalardo

Un risultato che conferma la capacitร  della ricerca italiana di incidere nel panorama scientifico internazionale e di contribuire alla costruzione di una sanitร  piรน rapida, mirata e sostenibile.


๐ŸŽ€ October is Breast Cancer Awareness Month

We at the Combine Group, Universitร  di Catania Department of Drug and Health Sciences, join this awareness campaign with our contribution from the world of ๐ข๐ง ๐ฌ๐ข๐ฅ๐ข๐œ๐จ ๐ฆ๐ž๐๐ข๐œ๐ข๐ง๐ž

Throughout this month, we will share insights, data, and perspectives on how research and new technologies can support prevention and treatment.

๐Ÿ’กPrevention starts with information

๐Ÿ‘‰ Follow us on LinkedIn Combine Group


๐Ÿ– ๐Œ๐š๐ ๐ ๐ข๐จ ๐Ÿ๐ŸŽ๐Ÿ๐Ÿ“ โ€“ ๐๐‡๐€๐‘๐Œ๐€ ๐ƒ๐€๐˜ ๐ƒ๐ข๐ฉ๐š๐ซ๐ญ๐ข๐ฆ๐ž๐ง๐ญ๐จ ๐๐ข ๐’๐œ๐ข๐ž๐ง๐ณ๐ž ๐๐ž๐ฅ ๐…๐š๐ซ๐ฆ๐š๐œ๐จ ๐ž ๐๐ž๐ฅ๐ฅ๐š ๐’๐š๐ฅ๐ฎ๐ญ๐ž, ๐”๐ง๐ข๐ฏ๐ž๐ซ๐ฌ๐ข๐ญร  ๐๐ข๐‚๐š๐ญ๐š๐ง๐ข๐š

Una giornata ricca di confronto e innovazione quella del Pharma Day, che ha visto protagonisti studenti, docenti e ricercatori del Dipartimento di Scienze del Farmaco e della Salute  dellโ€™ Universitร  di Catania

Anche il ๐‚๐จ๐ฆ๐›๐ข๐ง๐ž ๐†๐ซ๐จ๐ฎ๐ฉ ha avuto il piacere di presentare una serie di ๐ฉ๐จ๐ฌ๐ญ๐ž๐ซ ๐ฌ๐œ๐ข๐ž๐ง๐ญ๐ข๐Ÿ๐ข๐œ๐ข, illustrando le attivitร  di ricerca in ambito farmacologico e computazionale, con un focus su ๐ฆ๐จ๐๐ž๐ฅ๐ฅ๐ข ๐ฉ๐ซ๐ž๐๐ข๐ญ๐ญ๐ข๐ฏ๐ข e ๐ฌ๐ข๐ฆ๐ฎ๐ฅ๐š๐ณ๐ข๐จ๐ง๐ข ๐š๐ฏ๐š๐ง๐ณ๐š๐ญ๐ž.

Nel pomeriggio si รจ tenuto un intervento incentrato sul ๐ฌ๐ข๐ฆ๐ฎ๐ฅ๐š๐ญ๐จ๐ซ๐ž ๐”๐ˆ๐’๐’ (๐”๐ง๐ข๐ฏ๐ž๐ซ๐ฌ๐š๐ฅ ๐ˆ๐ฆ๐ฆ๐ฎ๐ง๐ž ๐’๐ฒ๐ฌ๐ญ๐ž๐ฆ๐’๐ข๐ฆ๐ฎ๐ฅ๐š๐ญ๐จ๐ซ), sviluppato allโ€™interno del Combine Group. Durante la presentazione sono state illustrate le sue potenzialitร  come strumento avanzato per la ๐ซ๐ข๐œ๐ž๐ซ๐œ๐š ๐ฉ๐ซ๐ž๐œ๐ฅ๐ข๐ง๐ข๐œ๐š ๐ž ๐œ๐ฅ๐ข๐ง๐ข๐œ๐š, in particolare nel contesto della ๐ฆ๐ž๐๐ข๐œ๐ข๐ง๐š ๐ฉ๐ž๐ซ๐ฌ๐จ๐ง๐š๐ฅ๐ข๐ณ๐ณ๐š๐ญ๐š e della valutazione di ๐ฌ๐ญ๐ซ๐š๐ญ๐ž๐ ๐ข๐ž ๐ญ๐ž๐ซ๐š๐ฉ๐ž๐ฎ๐ญ๐ข๐œ๐ก๐ž ๐ข๐ง๐ง๐จ๐ฏ๐š๐ญ๐ข๐ฏ๐ž.

Tra i punti salienti, รจ stato evidenziato che ๐ฎ๐ง๐š ๐ฌ๐จ๐ฅ๐ฎ๐ณ๐ข๐จ๐ง๐ž ๐”๐ˆ๐’๐’ ๐๐ž๐๐ข๐œ๐š๐ญ๐š ๐š๐ฅ๐ฅ๐š ๐ญ๐ฎ๐›๐ž๐ซ๐œ๐จ๐ฅ๐จ๐ฌ๐ข (๐”๐ˆ๐’๐’-๐“๐) ๐ก๐š ๐ซ๐ข๐œ๐ž๐ฏ๐ฎ๐ญ๐จ ๐ฎ๐ง๐š ๐ฅ๐ž๐ญ๐ญ๐ž๐ซ๐š ๐๐ข ๐ฌ๐ฎ๐ฉ๐ฉ๐จ๐ซ๐ญ๐จ ๐๐š ๐ฉ๐š๐ซ๐ญ๐ž ๐๐ž๐ฅ๐ฅโ€™๐„๐Œ๐€ (๐„๐ฎ๐ซ๐จ๐ฉ๐ž๐š๐ง ๐Œ๐ž๐๐ข๐œ๐ข๐ง๐ž๐ฌ ๐€๐ ๐ž๐ง๐œ๐ฒ), riconoscendone il valore scientifico e applicativo.

Un sentito ringraziamento a tutti i partecipanti per aver contribuito a rendere il Pharma Day unโ€™occasione di ๐œ๐ซ๐ž๐ฌ๐œ๐ข๐ญ๐š, ๐œ๐จ๐ง๐๐ข๐ฏ๐ข๐ฌ๐ข๐จ๐ง๐ž ๐ž ๐ข๐ฌ๐ฉ๐ข๐ซ๐š๐ณ๐ข๐จ๐ง๐ž ๐ฌ๐œ๐ข๐ž๐ง๐ญ๐ข๐Ÿ๐ข๐œ๐š.


Prof Francesco Pappalardo Explores Innovative In Silico Approaches at Biomathematics Workshop

The workshop “New Trends in Biomathematics – Applications in Oncology and Immunology” was held today, June 21, 2024, at Universitร  degli Studi Mediterranea di Reggio Calabria. This event brought together experts and enthusiasts from various fields to discuss the latest advancements in the application of mathematical models to medical research.

๐ŸŽ™๏ธ Presentations by Prof. Francesco Pappalardo:

Beyond the Data: Computational Modeling as a Tool in Oncology and Immunology
Simulating to Predict: Computational Models in Infectious Diseases
Prof. Francesco Pappalardo’s presentations highlighted the transformative potential of in silico medicine, a field that uses computational models to simulate biological processes. These techniques promise to revolutionize healthcare by reducing the costs and time required for drug development.

๐Ÿ”น Key Insights:

In Silico Medicine: Prof. Pappalardo illustrated how computational modeling can enhance our understanding of disease mechanisms, optimize drug development, and personalize treatments.
Revolutionizing Healthcare: By simulating clinical trials and predicting treatment outcomes, in silico methods offer a more efficient and ethical approach to medical research.
The workshop aimed to review the state of the art in mathematics applied to oncology and immunology, identifying emerging trends and strategies to advance the field. This gathering was of significant interest not only to experts in mathematical modeling and bioinformatics but also to doctors, biologists, and researchers in life and health sciences.

๐Ÿ”ฌ The event underscored the importance of interdisciplinary collaboration in pushing the boundaries of medical research. By integrating computational techniques with traditional medical practices, we can look forward to a future where healthcare is more precise, efficient, and personalized.

Stay tuned for more updates on the latest trends and breakthroughs in biomathematics and its applications in medicine.


Join Us for an Exciting Event on Pharmaceutical Research!

On Wednesday, May 15th, at 12:00 PM, in Classroom F (Building 2, University City), don’t miss the chance to meet Professor Francesco Pappalardo and Professor Giulia Russo from the DSFS! ๐ŸŽ“

๐Ÿ” Event Theme: “Impact of In Silico Trials on the Pharmaceutical World: Regulatory Challenges and Opportunities for Pharmaceutical and Health Sciences Students.” ๐Ÿ“Š

๐Ÿง  Discover the revolutionary Universal Immune System Simulator (UISS), developed by the Combine Group. This cutting-edge computational framework promises to transform the pharmaceutical industry! ๐Ÿ’ก

From predicting vaccination strategies to identifying molecular targets to overcome drug resistance, UISS offers a broad spectrum of possibilities that will revolutionize the future of pharmaceutical research. ๐Ÿ’Š

๐Ÿ‘ฉโ€๐Ÿ”ฌ Students, especially those in the final years of their degree programs, are encouraged to attend and immerse themselves in this field of excellence from our department. Donโ€™t miss out! ๐Ÿš€

PharmaceuticalResearch #InSilico #UISS #DSFS #UniversityOfCatania


First annual meeting (Switzerland, 2024)

Welcome to our latest update on the groundbreaking initiatives in tuberculosis research! As we delve into the world of tuberculosis consortium partnerships, we are excited to share the progress made in developing novel therapeutic options, improving outcomes, and preventing relapse. Our collaborative efforts aim to bring about transformative changes in tuberculosis treatment, with a focus on shortening treatment duration.

โš• In Vivo Evaluation of Immunotherapies

A major focus of our research involves the in vivo evaluation of the most promising immunotherapies. By combining these therapies with traditional approaches like chemotherapy or therapeutic vaccines, we aim to enhance their efficacy and potentially shorten the overall treatment duration. This approach holds great promise in revolutionizing tuberculosis treatment protocols.

โš• In Silico Modeling for Preclinical Progression

Harnessing the power of technology, our consortium employs in silico modeling to facilitate both in vitro and in vivo preclinical progression. This cutting-edge approach allows us to simulate and predict the therapeutic effects of potential treatments in the clinic. By utilizing advanced computational methods, we can streamline the research process, saving valuable time and resources.

One of the Goals: Develop Novel Therapeutic Options

Our consortium is committed to pushing the boundaries of tuberculosis research by developing innovative therapeutic options. The goal is to create treatments that not only effectively combat the disease but also have the potential to significantly reduce the duration of treatment. By leveraging the collective expertise of our partners, we are exploring new avenues for drug development and testing.

โš• Improve Outcomes and Prevent Relapse

Achieving better outcomes for tuberculosis patients is at the forefront of our collaborative efforts. We are dedicated to identifying strategies that not only cure the infection but also prevent relapses. Our consortium recognizes the importance of sustained recovery, and our research is geared towards finding solutions that ensure long-term success in tuberculosis treatment.

โš— Reflecting on Achievements and Future Goals

As we come together to discuss the accomplishments of the past year, we express our gratitude for the opportunity to collaborate and make significant strides in tuberculosis research. Our consortium’s dedication to advancing the field is evident in the milestones achieved, from the development of novel therapeutic options to the successful in vivo evaluation of immunotherapies.

Looking ahead, our future goals include expanding our collaborative efforts, integrating new research findings, and continuously striving for innovative solutions to combat tuberculosis. We are excited about the possibilities that lie ahead and are confident that our collective endeavors will contribute to the global fight against this infectious disease.

In conclusion, our tuberculosis consortium is making significant progress in reshaping the landscape of tuberculosis research. By fostering collaboration, embracing innovation, and reflecting on our achievements, we are committed to bringing about positive change in the lives of those affected by tuberculosis. Together, we are on the path to transforming the future of tuberculosis treatment. Thank you for your ongoing support and partnership in this important endeavor.


Pint of Science 2023

รˆ possibile creare una replica digitale di un paziente, in grado di anticipare le variazioni nel suo stato di salute e fornire un valido supporto decisionale per la gestione clinica? Grazie agli avanzamenti nelle tecnologie informatiche di ultima generazione, oggi possiamo integrare e analizzare tutte le informazioni disponibili per un singolo paziente, consentendoci di predire l’andamento della sua salute in specifiche condizioni. Il Professor Francesco Pappalardo approfondirร  questo argomento e altri aspetti affascinanti, il tutto in un’atmosfera informale, davanti a una piacevole pinta di birra



Sharper Night

Catania ha recentemente celebrato e sottolineato l’importanza della ricerca attraverso la partecipazione alla Notte Europea dei Ricercatori. La cittร  ha ideato un ricco programma che abbraccia una vasta gamma di temi, spaziando dalla ricerca di base alle applicazioni tecnologiche in campi diversificati. L’interdisciplinarietร  e le sfide per il futuro hanno guidato l’intero programma, creando un filo conduttore che ha accentuato la diversitร  e la portata delle iniziative presentate durante l’evento.

Event link: https://www.sharper-night.it/evento/conferenza-universita-imprenditoriale/


4 April 2023 – Les Diablerets (Switzerland)


UISS, il paziente virtuale โ€“ Radio24 (IlSole24Ore)

Evitare, o ridurre al lumicino, la sperimentazione sugli animali; accelerare il processo di approvazione dei farmaci e scansare i vicoli ciechi nella ricerca.
Sono questi gli obiettivi cui punta un gruppo di ricercatori dell’Universitร  di Catania con Uiss, il paziente virtuale. Uiss sta per Universal Immune System Simulator, รจ frutto di un quindicennio di lavoro degli scienziati catanesi e rientra a pieno titolo in quel settore della medicina computazionale.
Come dice il nome, parliamo di un software che รจ in grado di simulare il comportamento del sistema immunitario di un individuo (e anche di gruppi di individui, ognuno con caratteristiche immunitarie diverse) di fronte all’aggressione di un patogeno e in presenza di un farmaco. Giร  sperimentato su varie patologie, oggi viene applicato, non sorprendentemente, anche alla Covid.
Ospite Francesco Pappalardo, Professor in Computer Science del Dipartimento di Scienze del Farmaco dell’Universitร  di Catania.

COVID-19, la ricerca accende i riflettori sull’argomento vaccini โ€“ Radio Fantastica

COVID-19, la ricerca accende i riflettori sull’argomento vaccini โ€“ Radio Fantastica
Su Radio Fantastica รจ intervenuto il Prof. Francesco Pappalardo docente di Informatica dell’Universitร  degli Studi di Catania.